Expression of uPA and VEGF:Association with Invasion and Metastasis in Nasopharyngeal Carcinoma

Objective To investigate the relationship between expression of uPA (urokinase type plasmiongen activator,uPA)and VEGF(Vascular endothelial growth factor,VEGF)and invasion and metastasis of nasopharyngeal carcinoma (NPC).Methods Expression of uPA and VEGF using immunohistochemical LASB stainning,Paraffin embedded specimens of 45 patients with NPC were detected.All ptients were folowed up 3 years.Results The positive rate of uPA and VEGF were significantly higher in cases with recurrence (R NPC) and in cases with lymph node involvement (LN+) than those without recurrence(NR NPC)or lymph node involvement(LN );expressions of uPA had positive correlated with VEGF.Conclusion uPA and VEGF are closely correlated with invasion and metastasis of NPC,which may contribute to tumor development,invasion and metastasis.