Abstract 17591: Impact of Renal Dysfunction on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention Who Have Concomitant Atrial Fibrillation: From the CREDO-Kyoto Registry Cohort-2

Background: Clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) with atrial fibrillation (AF) and chronic kidney disease (CKD) have not yet been fully elucidated. Methods and Results: Among 12716 patients undergoing PCI in the CREDO-Kyoto Registry Cohort-2, 1057 (8.3%) had AF. The AF patients were divided into 3 groups according to estimated glomerular filtration rate (eGFR); non-CKD (eGFR>=60, n=491), mild-CKD (eGFR=30-60, n=448), and severe-CKD (eGFR<30 or on hemodialysis, n=107) groups. Compared with non-CKD patients, mild- and severe-CKD patients were older (70.1±9.2, 74.8±8.7, and 74.2±9.5, P<0.001). Prevalence of oral anticoagulation (OAC) with warfarin at hospital discharge was 48%, 49%, and 44%, respectively (P=NS). Median follow-up duration was 5.1 years. AF was independently associated with stroke (adjusted hazard ratio [HR] 2.00, 95% confidence interval [CI] 1.65-2.43). The 5-year risk of stroke in AF patients with non-, mild-, and severe-CKD was 8.9%, 13.7%, and 3...