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In Vivo Decreased Dopamine Transporter Uptake in Corticobasal Degeneration Presenting with Primary Progressive Aphasia Without Parkinsonism

European Journal Of Neurology(2014)SCI 2区

Hospital Clínic de Barcelona | Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

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Abstract
S.Gil-Navarro, E.Gelpi, F. Lome~ na, N. Montagut, A. Llad o, J. L.Molinuevo andR. S anchez-Valle Alzheimer’s Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Cl ınic, Barcelona; Neurological Tissue Bank of the Biobank, Hospital Clinic, IDIBAPS, Barcelona; Nuclear Medicine Department, Hospital Cl ınic, Barcelona; and Institut d’Investigaci o Biom edica August Pi I Sunyer (IDIBAPS) Barcelona, Spain
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要点】:本文研究了在表现为原发性进行性失语症的非帕金森型皮质基底变性患者中,多巴胺转运体摄取的减少情况,并揭示了该现象与疾病进展的关联。

方法】:通过在体多巴胺转运体显像技术,对患者的脑部多巴胺转运体摄取进行评估。

实验】:在实验中,作者使用SPECT成像技术对参与者进行了多巴胺转运体显像,使用的数据集名称未明确提及,结果显示患者表现出明显的多巴胺转运体摄取减少。