Hipk1 Interference Attenuates Inflammation And Oxidative Stress Of Acute Lung Injury Via Autophagy

Background: Acute respiratory distress syndrome (ARDS), which is characterized by severe hypoxemia (PaO2/FIO2 <= 300 mmHg), is usually companied by uncontrolled inflammation, oxidative injury, and the damage to the alveolar-capillary barrier. Severe ARDS is usually companied with acute lung injury that worsen the patients' condition. HIPK1 is a modulator of homeodomain-containing transcription factors and regulates multiple cellular biological process associated with inflammation and anti-stress responses.Material/Methods: We used an LPS-induced mouse acute lung injury (ALI) model to investigate the possible role of HIPK1 in ALI pathophysiology.Results: We found the HIPK1 was elevated in ALI model mice while interference of HIPK1 by siRNA attenuated the inflammation and oxidative stress indicators (H2O2, O-2(-), and NO). Further research found HIPK1 interference enhanced the autophagy.Conclusions: Decreased HIPK1 in ALI showed protective effects in attenuating inflammation and oxidative stress and enhancing autophagy, indicating HIPK1 as a possible target in ALI management.