Oncogenic Basic Amino Acid Insertions at the Extracellular Juxtamembrane Region of IL7RA Cause Receptor Hypersensitivity.

Livia Weijenborg Campos,Priscila Pini Zenatti,Leonardo Granato Pissinato, Gisele O. Libanio Rodrigues,Leonardo Luís Artico, Thais Rafael Guimarães,Leticia Fröhlich Archangelo,Leandro Martínez,Andrew J. Brooks,José Andrés Yunes

Blood（2019）

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摘要

TO THE EDITOR: The receptor for interleukin-7 (IL-7) is formed by the IL7RA and the IL2RG (γc) chains. IL-7 leads to the reciprocal phosphorylation of IL7RA-associated JAK1 and γc-associated JAK3, followed by phosphorylation of IL7RA and then STAT5 anchoring and activation. Constitutive signaling

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NK Cell Receptors

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