Role of corticosterone in altered neurobehavioral responses to acute stress in a model of compromised hypothalamic-pituitary-adrenal axis function.

•HPA disruption in mice changes acute stress-coping behaviors.•Changes in coping behaviors are associated with altered brain FOS responses.•Acute corticosterone manipulation does not rescue or mimic neurobehavioral effects.•Suggests long-term HPA disruption causes remodeling of brain stress circuits.