Long-term survival in patients with advanced non-small-cell lung cancer treated with atezolizumab versus docetaxel: Results from the randomised phase III OAK study.

J von Pawel,R Bordoni, M Satouchi, L Fehrenbacher,M Cobo,J Y Han,T Hida, D Moro-Sibilot,P Conkling, D R Gandara,A Rittmeyer,M Gandhi,W Yu, C Matheny,H Patel,A Sandler,M Ballinger,M Kowanetz,K Park

European Journal of Cancer(2019)

引用 91|浏览47
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摘要
•Atezolizumab provided durable survival benefit across all best-response subgroups.•Atezolizumab long-term survivors (LTSs) were enriched for high programmed death-ligand 1 (PD-L1) expression.•Atezolizumab LTSs also included patients with PD-L1–negative tumours.•Atezolizumab LTSs included patients with progressive disease as best response.•Extended atezolizumab exposure showed tolerable safety in LTS.
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关键词
Atezolizumab,Long-term survival,Second-line NSCLC,PD-L1,Cancer immunotherapy
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