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5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy.

Xiao Ding,Luigi Piero Stasi,Xuedong Dai,Kai Long,Cheng Peng,Baowei Zhao,Hailong Wang,Changhui Sun,Huan Hu,Zehong Wan,Karamjit S Jandu,Oliver J Philps,Yan Chen,Lizhen Wang,Qian Liu,Colin Edge,Yi Li,Kelly Dong,Xiaoming Guan,F David Tattersall,Alastair D Reith,Feng Ren

Bioorganic & Medicinal Chemistry Letters（2019）

引用 10|浏览47
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关键词
CNS penetration,LRRK2,Parkinson’s disease,PFI,Unbound fraction
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