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Haematological malignancies following temozolomide treatment for paediatric high-grade glioma.

Michael Karremann,Nadja Krämer,Marion Hoffmann,Maria Wiese,Andreas Beilken,Selim Corbacioglu,Dagmar Dilloo,Pablo Hernáiz Driever,Wolfram Scheurlen,Andreas Kulozik,Gerrit H Gielen,André O von Bueren,Matthias Dürken,Christof M Kramm

European Journal of Cancer（2017）

Cited 4|Views51
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Abstract
•The 10-year incidence of secondary haematological malignancies (SHMs) following paediatric high-grade glioma is estimated 7.7 ± 3.2%.•First-line temozolomide seems not to increase the risk of SHMs compared with multiagent chemotherapy.•Second-line temozolomide may disproportionately increase the risk of SHMs.
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Key words
Children,Glioblastoma,High-grade glioma,Secondary haematological malignancies
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