Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2.
ONCOTARGET(2017)
摘要
Lung cancer is the leading cause of cancer related death which needs novel drugs to improve patient outcomes. In this study, we examined the ability of YF-18, a novel matrine derivative to inhibit the growth and migration of lung cancer cells. By cell cycle analysis, wound healing and transwell assays, we found that YF-18 induced G2/M cell cycle arrest and inhibited migration of lung cancer cells in a dose-dependent manner. Further results indicated that YF-18 inhibited cell proliferation and migration through down-regulating Skp2 and up-regulating its substrates, p27 and E-cadherin. Moreover, YF-18 inhibited A549-luciferase cell xenograft tumor growth in a dosedependent manner. The findings indicate that YF-18 bears therapeutic potentials for
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关键词
lung cancer,matrine derivative,Skp2,proliferation,migration
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