Effect of Multiple Oral Doses of the Potent CYP3A4 Inhibitor Clarithromycin on the Pharmacokinetics of a Single Oral Dose of Vonoprazan: A Phase I, Open-Label, Sequential Design Study.

Helen Jenkins,Richard Jenkins,Alain Patat

Clinical drug investigation（2016）

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摘要

This phase I, open-label, sequential design study assessed the effect of multiple oral doses of the potent cytochrome P450 (CYP) 3A4 inhibitor clarithromycin on the pharmacokinetics of a single oral dose of vonoprazan.

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关键词

Clarithromycin,Single Oral Dose,Gastric Acid Secretion,Multiple Oral Dose,Potent CYP3A4 Inhibitor

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