Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism
L. Nathan Tumey,Carolyn A. Leverett,Beth Vetelino,Fengping Li,Brian Rago,Xiaogang Han,Frank Loganzo,Sylvia Musto,Guoyun Bai,Sai Chetan K. Sukuru,Edmund I. Graziani,Sujiet Puthenveetil,Jeffrey Casavant,Anokha Ratnayake,Kimberly Marquette,Sarah Hudson,Venkata Ramana Doppalapudi,Joseph Stock,Lioudmila Tchistiakova,Andrew J. Bessire,Tracey Clark,Judy Lucas,Christine Hosselet,Christopher J. O'Donnell,Chakrapani Subramanyam ACS Medicinal Chemistry Letters（2016）
关键词
Antibody-drug conjugate (ADC),tubulysin,hydrophobic interaction chromatograph (HIC),plasma stability
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