A Novel Mutation in the DNA Binding Domain of NFKB is Associated with Speckled Leukoplakia.

The identification of a substitution mutation L140Q within the DNA binding domain of NFKB in OL suggests that NFKB mutation may be relatively an early event during transformation. To the best of our knowledge, this study is the first to have identified a missense mutation in NFKB in OL.