Sarcopenia Associated with Renal Function in the Patients with Type 2 Diabetes

Aims: Studies have suggested that low muscle mass is associated with declining renal function in healthy populations, whether the association is relevant to patients with type 2 diabetes is not well understood. This study investigates the association between sarcopenia and estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratios (UACR) in the patients with type 2 diabetes.Methods: Two recruited groups consisted of 793 persons without diabetes (males/females = 550/243) and 762 persons with type 2 diabetes (males/females = 501/261).Results: The non-sarcopenia population demonstrated higher ASM/HT2, GFR (P < 0.001) and lower UACR (P < 0.05) than the sarcopenia population. In studied men, the association between ASM/HT2 and eGFR was statistically significant in the group without diabetes (OR = 0.580, P = 0.020), a trend which persisted in women (OR = 0.491, P = 0.014). The association between ASM/HT2 and UACR persisted in studied women of two groups (OR = 0.269, P = 0.005; OR = 0.405, P = 0.008, respectively). The highest quartile of ASM/HT2 in the non-sarcopenia population exhibited a 3.753-fold risk of abnormal eGFR within the diabetes group (OR = 3.753, P = 0.020). The cutoff point of ASM/HT2 to indicate abnormal renal function for population with non-sarcopenia was 6.32 kg/m(2) in the group without diabetes and 6.31 kg/m(2) in diabetes group.Conclusions: Sarcopenia is associated with declining renal function, which induces lower eGFR and higher UACR. In the non-sarcopenia population, ASM/HT2 presents as renal function risk factor, which perhaps associated with higher muscle mass to induce a greater underestimation for creatinine and urinary albumin. (C) 2016 Elsevier Ireland Ltd. All rights reserved.