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Orally Administered Hyaluronan Affects Skin Dryness and Epidermal Thickening in Photoaged Hairless Mice

Chinatsu Kawada,Mamoru Kimura,Yasunobu Masuda,Yoshihiro Nomura

Bioscience, biotechnology, and biochemistry（2016）

Cited 4|Views5
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Abstract
The oral administration of hyaluronans (HAs) (molecular weight, 300k and less than 10k) to photoaged hairless mice increased the moisture content of the stratum corneum and decreased the epidermal thickness, respectively. Furthermore, orally administered HAs suppressed the low-molecular weight of HA content of the skin. This study indicates oral administered HAs may ameliorate the skin condition resulting from photoaging.
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Key words
hyaluronan,photoaging,ultraviolet irradiation,moisture content of stratum corneum,epidermal thickening
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