Characterization of cysteine related variants in an IgG2 antibody by LC-MS with an automated data analysis approach.

Yuling Zhang,Robert Bailey,Nancy Nightlinger, Alison Gillespie,Alain Balland,Richard Rogers

Journal of Chromatography B（2015）

引用 10|浏览7

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摘要

•Disulfide variants and free SHs of an antibody were separated and characterized.•Automated data analysis was used, enabling high-throughput relative quantification.•Peptide templates were created for various disulfide linkages and free SHs.•Large sample sets can be quickly analyzed.

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关键词

IgG2,Monoclonal antibody,Disulfide,Free sulfhydryls and cysteine,LC–MS,nrRP-HPLC,Pinpoint software

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