[The synthesis of ψ-(2-aryl-1,3-dioxolan-2-yl) alkyl derivatives of purines and their activity towards HIV reverse transcriptase].

V V Komissarov,V T Valuev-Elliston,O N Ivanova,S N Kochetkov,A M Kritzyn

Bioorganicheskaia khimiia（2015）

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摘要

Novel non-competitive inhibitors of HIV RT were synthesized by alkylation of 6-substituted purines with different 2-(chloroalkyl)-2-aryl-1,3-dioxolanes and related compounds. The structure-activity relationship within the synthesized compounds was studied.

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