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Grainyhead-like-2 Confers NK-sensitivity Through Interactions with Epigenetic Modifiers

Ian MacFawn,Hannah Wilson,Luke A. Selth, Ian Leighton,Ilya Serebriiskii,R. Christopher Bleackley,Osama Elzamzamy,Joshua Farris,Phillip M. Pifer,Jennifer Richer,Steven M. Frisch

Molecular Immunology（2019）

Cited 18|Views26
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Abstract
•GRHL2 is a master programmer of the epithelial phenotype that sensitized cells to NK killing at the level of NK-target cell synaptogenesis.•Sensitization was mediated by the up-regulation of ICAM-1.•GRHL2-KMT2C/D interactions and p300 inhibition were important for MET, ICAM-1 up-regulation and NK-sensitization effects.•ICAM-1 expression correlated significantly with GRHL2 expression in lung tumors.
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Key words
Grainyhead-like-2,NK cells,ICAM-1,Mesenchymal-to-epithelial transition,KMT2C,KMT2D,Epigenetic,p300
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