Impact of Splitting or Crushing on the Relative Bioavailability of the Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Single‐Tablet Regimen

Kimberley Brown, David Thomas, Kevin McKenney, Michael Reeder,Richard Bruce Simonson,Ceyhun Bicer,Richard E. Nettles,Herta Crauwels

CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT（2019）

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关键词
human immunodeficiency virus-1,darunavir,tenofovir alafenamide,pharmacokinetics,bioavailability,single-tablet regimen,crushed tablet,split tablet
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