Stereoselective Synthesis Of Functionalized Alpha-Amino Acids Isolated By Filtration
JOURNAL OF ORGANIC CHEMISTRY(2018)
摘要
Crystallization-induced diastereomer transformation (CIDT) represents a highly appealing and convenient synthetic tool. Despite its numerous advantages, it remains rather rarely used due to its uncertain predictability to occur. Herein, we describe CIDT based on aza-Michael reactions of diversely functionalized (E)-3-acylacrylic acids. This method provides direct access to a broad variety of alpha-amino acid derivatives in excellent stereochemical purities.
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