Lower Expression of Bax Predicts Poor Clinical Outcome in Patients with Glioma after Curative Resection and Radiotherapy/chemotherapy

The prognosis in patients with gliomas after surgical resection followed by radiotherapy and/or chemotherapy is still very poor. The pro-apoptotic protein Bax, a short-lived protein in cancers, plays important roles in the sensitivity of glioma cells to spontaneous and therapy-induced apoptosis but and its prognostic value in gliomas is unknown.