Lamina Cribrosa And Choroid Features And Their Relationship To Stage Of Pseudoexfoliation Glaucoma

PURPOSE. To better understand the relationship of lamina cribrosa (LC) and choroid features to the severity of pseudoexfoliation glaucoma (PXG).METHODS. In this cross-sectional study, 137 eyes of 122 subjects (47 eyes with moderate/ advanced PXG [mean deviation (MD), 15.0 6 7.7 dB], 34 eyes with mild PXG [MD, 2.7 6 1.5 dB], 32 aged-matched pseudoexfoliation syndrome [PXS] eyes, and 24 aged-matched control eyes) were investigated. Optic discs, LC thickness, and anterior LC depth (ALD; midsuperior, center, and midinferior) as well as peripapillary choroidal thickness were determined. Linear mixed modeling was used to adjust for age, sex, and axial length.RESULTS. A progressive decrease in LC thickness was found when comparing controls (271.9 6 61.3 lm), PXS (212.6 6 51.5 lm), mild PXG (180.8 6 24.6 lm), and moderate/advance PXG (138.9 6 37.5 lm) (P < 0.001). ALD was greater (P < 0.001) in moderate/advance glaucoma (306.7 6 105.3 lm) and mild PXG (209.5 6 79.7 lm) compared with PXS (155 6 86.7 lm) and healthy controls (149.2 6 103 lm). Although eyes with moderate/advance PXG had the thinnest choroid (117.2 6 36.6 lm), choroidal thickness was comparable in mild PXG, PXS, and controls (150.0 6 46.1, 159.7 6 65.5, and 157.5 6 51.1 lm, respectively; P = 0.002). Worse MD was the only factor associated with thinner LC (b = 2.344, P < 0.001) and choroid (b = 1.717, P = 0.009 lm) in PXG eyes. Higher IOP (b = 4.305, P = 0.013) and worse MD (b = 6.390, P < 0.001) were associated with deeper ALD in PXG.CONCLUSIONS. In pseudoexfoliation, LC thinning is an early sign, and there is progressive thinning with advancing glaucoma. Choroidal thinning is observable only with moderate/ advanced glaucoma. In PXG eyes, LC thickness, depth, and peripapillary choroidal thickness are associated with glaucoma severity.