Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Ca 2.2) blockers for the treatment of pain.

Mark J Wall,Nalin L Subasinghe,Michael P Winters,Mary Lou Lubin,Michael F A Finley,Ning Qin,Michael R Brandt,Michael P Neeper,Craig R Schneider,Raymond W Colburn,Christopher M Flores,Zhihua Sui

Bioorganic & Medicinal Chemistry Letters（2018）

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关键词

Pain,N-type calcium channel,Cav 2.2,Pyrazoles,CFA model,CCI model

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