SOX2 Regulates Radioresistance in Cervical Cancer Via the Hedgehog Signaling Pathway.

Chunxian Huang,Huaiwu Lu,Jing Li,Xiaofei Xie,Li Fan,Dongyan Wang,Wenliang Tan,Yaxian Wang,Zhongqiu Lin,Tingting Yao

Gynecologic Oncology（2018）

引用 35|浏览25

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摘要

•SOX2 is highly expressed in acquired radioresistant cervical cancer cells.•SOX2 overexpression enhances the resistance to irradiation.•SOX2 suppression improves the sensitivity to irradiation.•SOX2 mediates the radioresistance via the Hh signaling pathway.•SOX2 directly occupies the promoter of HHAT.

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关键词

SOX2,Hedgehog signaling pathway,Radioresistance,Irradiation,Cervical cancer

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