Plasma Interleukin-37 is Increased and Inhibits the Production of Inflammatory Cytokines in Peripheral Blood Mononuclear Cells in Systemic Juvenile Idiopathic Arthritis Patients

Interleukin (IL)-37 has emerged as a novel anti-inflammatory cytokine that play an immunosuppressive role in regulating inflammatory response. This study aimed to measure IL-37 levels in the plasma and peripheral blood mononuclear cells (PBMCs) of patients with systemic juvenile idiopathic arthritis (sJIA), and to establish the correlation between IL-37 levels and disease activity, laboratory parameters and inflammatory cytokines.