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Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.

Jason R Abbott,Pratiq A Patel,Jennifer E Howes,Denis T Akan,J Phillip Kennedy,Michael C Burns,Carrie F Browning,Qi Sun,Olivia W Rossanese,Jason Phan,Alex G Waterson,Stephen W Fesik

ACS medicinal chemistry letters（2018）

引用 23|浏览20
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关键词
RAS,SOS1,nucleotide exchange,structure-based design,quinazolines
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