A Novel Nucleic Acid Aptamer Tag: a Rapid Fluorescence Strategy Using a Self-Constructing G-quadruplex from AGG Trinucleotide Repeats

Herein, we have developed a novel fluorescence labeling strategy for nucleic acid aptamers based on self-assembling between AGG tri-nucleotide repeats and a pyrene-modified oligonucleotide. This strategy could be an effective tool for developing targeting-imaging systems and biosensor systems to detect target molecules.