Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitors.

Hui Qiu,Lesley Liu-Bujalski,Richard D Caldwell,Ariele Viacava Follis,Anna Gardberg,Andreas Goutopoulos,Roland Grenningloh,Jared Head,Theresa Johnson,Christopher C V Jones,Reinaldo Jones,Igor Mochalkin,Federica Morandi,Constantin Neagu,Justin Potnick,Brian Sherer

Bioorganic & Medicinal Chemistry Letters（2018）

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Btk inhibitor,Efflux ratio,tPSA,cLogP,Steric hindrance

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