Early Stage Periarticular Injection During Total Knee Arthroplasty May Provide a Better Postoperative Pain Relief Than Late-Stage Periarticular Injection: a Randomized-Controlled Trial.

This study was performed to determine whether periarticular injection performed in the early stage of total knee arthroplasty (TKA) could provide a better postoperative pain relief than periarticular injection performed in the late stage of TKA. The hypothesis was based on the concept that analgesic intervention before the onset of noxious stimuli would be associated with less postoperative pain.