Generation of Fcabs targeting human and murine LAG-3 as building blocks for novel bispecific antibody therapeutics.

Katy L Everett,Matthew Kraman,Francisca P G Wollerton,Carlo Zimarino,Katarzyna Kmiecik,Miguel Gaspar, Sarka Pechouckova,Natalie L Allen,Jacqueline F Doody,Mihriban Tuna

Methods（2019）

Cited 30|Views14

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Abstract

•Phage display was used to generate Fcabs targeting human and murine LAG-3.•These Fcabs block LAG-3 binding to its target and induce activity in a T cell assay.•Fcab properties are maintained when they are included in bispecific antibodies.

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Key words

BSA,DPBS,FACS,FBS,Fcab,GMFI,IMGT,LAG-3,mAb,MHC,MPBST,PBS,PBST,Phage fd,RT,SDS-PAGE,SE-HPLC,TIL,WT

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