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Uridine Depletion and Chemical Modification Increase Cas9 Mrna Activity and Reduce Immunogenicity Without HPLC Purification

Sriram Vaidyanathan,Krist T. Azizian,A. K. M. Ashiqul Haque,Jordana M. Henderson,Ayal Hendel,Sabrina Shore,Justin S. Antony,Richard Hogrefe,Michael S. D. Kormann,Matthew H. Porteus,Anton P. McCaffrey

Molecular therapy Nucleic acids（2018）

引用 154|浏览127
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关键词
mRNA,capping,Cas9,innate immunity,CRISPR,CleanCap,mRNA,uridine depletion,ARCA,Cap 1
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