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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).

Andrew Fensome,Catherine M. Ambler,Eric Arnold,Mary Ellen Banker,Matthew F. Brown,Jill Chrencik,James D. Clark,Martin E. Dowty,Ivan V. Efremov,Andrew Flick,Brian S. Gerstenberger,Ariamala Gopalsamy,Matthew M. Hayward,Martin Hegen,Brett D. Hollingshead,Jason Jussif,John D. Knafels,David C. Limburg,David Lin,Tsung H. Lin,Betsy S. Pierce,Eddine Saiah,Raman Sharma,Peter T. Symanowicz,Jean-Baptiste Telliez,John I. Trujillo,Felix F. Vajdos,Fabien Vincent,Zhao-Kui Wan,Li Xing,Xiaojing Yang,Xin Yang,Liying Zhang

Journal of Medicinal Chemistry（2018）

Cited 102|Views52
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Key words
cytokine signaling,Inflammatory Cytokines,Inflammation,Immune Responses
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