Past and Present Perspectives on Β-Lactamases
Antimicrobial Agents and Chemotherapy（2018）
Abstract
β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-negative bacteria, are ancient enzymes whose origins can be traced back millions of years ago. These well-studied enzymes, currently numbering almost 2,800 unique proteins, initially emerged from environmental sources, most likely to protect a producing bacterium from attack by naturally occurring β-lactams.
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ESBL,MBL,beta-lactam,beta-lactamase,carbapenemase,cephalosporinase,penicillinase
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