Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor As a Clinical Candidate for the Treatment of IBS.
Hilary Schenck Eidam,John Russell,Kaushik Raha,Michael DeMartino,Donghui Qin,Huiping Amy Guan,Zhiliu Zhang,Gong Zhen,Haiyu Yu,Chengde Wu,Yan Pan,Gerard Joberty,Nico Zinn,Sylvie Laquerre,Sharon Robinson,Angela White,Amanda Giddings,Ehsan Mohammadi,Beverly Greenwood-Van Meerveld,Allen Oliff,Sanjay Kumar,Mui Cheung ACS Medicinal Chemistry Letters（2018）
关键词
RET kinase,IBS,gut restricted,genotoxicity,AMES
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