Synthesis of Trifluoromethylated 2H-Azirines Through Togni Reagent-Mediated Trifluoromethylation Followed by PhIO-mediated Azirination
Beilstein journal of organic chemistry(2018)
摘要
The reaction of enamine compounds with the Togni reagent in the presence of CuI afforded β-trifluoromethylated enamine intermediates, which were converted directly to biologically interesting trifluoromethylated 2H-azirines by an iodosobenzene (PhIO)-mediated intramolecular azirination in a one-pot process.
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关键词
azirination,2H-azirine,iodosobenzene,Togni reagent,beta-trifluoromethylation
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