Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

Jara K. Brenke,Grzegorz M. Popowicz,Kenji Schorpp,Ina Rothenaigner,Manfred Roesner,Isabel Meininger, Cédric Kalinski,Larissa Ringelstetter, Omar R'kyek,Gerrit Jürjens,Michelle Vincendeau,Oliver Plettenburg,Michael Sattler,Daniel Krappmann,Kamyar Hadian

Journal of Biological Chemistry（2018）

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NF-kappaB,small molecule,protein-protein interaction,inflammation,autoimmunity,psoriasis,chemical biology,drug discovery,rheumatoid arthritis,TRAF6,Ubc13

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