Mitochondrial depletion in CD4 and CD19 peripheral lymphocytes in early stage Alzheimer's disease.
Mechanisms of Ageing and Development(2017)
摘要
•Mitochondrial depletion was analyzed in blood of Alzheimer’s disease (AD) patients.•mtDNA levels were decreased in CD4+, CD19+, C56+ lymphocytes at early stage AD.•The MFI of the mitochondria antibody was decreased in CD19+, CD56+ lymphocytes.•This study suggests mitochondrial depletion as a promising diagnostic target for AD.
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关键词
Alzheimer’s disease,Lymphocytes,Mitochondria,Mitochondrial depletion,mtDNA
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