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The Trem2 R47H Variant Confers Loss-of-function-like Phenotypes in Alzheimer's Disease.

Paul J. Cheng-Hathaway,Erin G. Reed-Geaghan,Taylor R. Jay,Brad T. Casali,Shane M. Bemiller,Shweta S. Puntambekar,Victoria E. von Saucken,Roxanne Y. Williams,J. Colleen Karlo,Miguel Moutinho,Guixiang Xu,Richard M. Ransohoff,Bruce T. Lamb,Gary E. Landreth

Molecular Neurodegeneration（2018）

引用 143|浏览46
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关键词
TREM2,Neuroinflammation,Innate immunity,CRISPR/Cas9,Single nucleotide polymorphism,Alzheimer’s disease
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