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Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.

Sobhana Babu Boga,Abdul-Basit Alhassan,Alan B Cooper,Ronald Doll,Neng-Yang Shih,Gerald Shipps,Yongqi Deng,Hugh Zhu,Yang Nan,Robert Sun,Liang Zhu,Jagdish Desai,Mehul Patel,Kiran Muppalla,Xiaolei Gao,James Wang,Xin Yao,Joseph Kelly,Subrahmanyam Gudipati,Sunil Paliwal,Hon-Chung Tsui,Tong Wang,Bradley Sherborne,Li Xiao,Alan Hruza,Alexei Buevich,Li-Kang Zhang,David Hesk,Ahmed A Samatar,Donna Carr,Brian Long,Stuart Black,Priya Dayananth,William Windsor,Paul Kirschmeier,Robert Bishop

Bioorganic & Medicinal Chemistry Letters（2018）

引用 11|浏览59
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关键词
ERK inhibitor,ATP competitive,MAP kinases,Kinase selectivity,Oncology
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