Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.

Bioorganic & Medicinal Chemistry Letters（2018）

引用 11|浏览58

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摘要

•Discovery of potent, selective and orally bioavailable ERK inhibitor for oncology.•Synthesis of tert 3-(S)thiomethyl pyrrolidine based ERK inhibitors.•Improved PK due to sulfur substitution-mitigation of amide bond cleavage.

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关键词

ERK inhibitor,ATP competitive,MAP kinases,Kinase selectivity,Oncology

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