Cognitive deficits induced by combined exposure of stress and alcohol mediated through oxidative stress-PARP pathway in the hippocampus.

•Restraint stress increases alcohol consumption in mice.•Combined exposure of alcohol and stress aggravates memory deficits.•Oxidative stress-PARP cascade gets activated in alcohol and stress-exposed mice.•1,5-isoquinolinediol ameliorates alcohol and stress-induced memory deficits.