Ultra‐high‐b Radial Diffusion‐weighted Imaging (uhb‐rdwi) of Human Cervical Spinal Cord

Background Injury in the cervical spinal cord (CSC) can lead to varying degrees of neurologic deficit and persistent disability. Diffusion tensor imaging (DTI) is a promising method to evaluate white matter integrity and pathology. However, the conventional DTI results are limited with respect to the specific details of neuropathology and microstructural architecture. In this study we used ultrahigh-b radial-DWI (UHb-rDWI) with b-values ranging from 0 to similar to 7500 s/mm(2) and calculated decay constant (D-H) at the high b-values, which gives much deeper insight about the microscopic environment of CSC white matter. Purpose To evaluate a novel diffusion MRI, UHb-rDWI technique for imaging of the CSC. Study Type Longitudinal. Subjects Four healthy controls, each scanned twice. Field Strength/Sequence 3T/2D single shot diffusion-weighted stimulated echo planar imaging with reduced field of view. Assessment The signal from each pixel of b(0) (b = 0) and b-value (b not equal 0) images were fitted to a biexponential function and normalized. The signal-b curve is obtained by dividing the latter curve by the former. D-H was obtained from the curve at b >4000 s/mm(2). A Monte-Carlo Simulation (MCS) was performed to investigate how D-H changes upon the increased water-exchange at the CSC. Results The signal-b curves plotted at multiple levels of healthy CSC are almost identical on two successive scans and show a biexponential decay behavior: fast exponential decay at lower b-values and much slower decay at UHb-values. The mean values of D-H were measured as (0.0607 +/- 0.02531) x10(-3) and (0.0357 +/- 0.02072) x10(-3) s/mm(2) at the lateral funiculus and posterior column, respectively. MCS of diffusion MRI shows that the D-H is elevated by increased water exchange between the intra- and extraaxonal spaces. Data Conclusion UHb-rDWI signal-b plots of the normal CSC were highly reproducible on successive scans and their biexponential decay behavior can be used to characterize normal spinal white matter. Level of Evidence: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:204-211.