5 '-Hydroxy-5 '-Homoaristeromycin: Synthesis and Antiviral Properties
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(2018)
摘要
Synthetically combining the C-4' side-chain structural features of the antiviral candidates 5'-methylaristeromycin and 5'-homoaristeromycin into a diastereomeric pair of C-4' side-chain dihydroxylated aristeromycins (6 and 7) is reported. Broad antiviral analyses of the both targets found promising effects towards HBV (6, 6.7 mu M and 7, 7.74 mu M) and HCMV (only 7, 0.72 mu M). No other activity was found. Neither of the diastereomers was cytotoxic in the assays performed. (C) 2018 Elsevier Ltd. All rights reserved.
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关键词
Carbocyclic nucleosides,C-4 ' aristeromycin derivatives,Hepatitis B,Cytomegalovirus
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