Pd-Catalyzed Decarboxylative Sonogashira Reaction via Decarboxylative Bromination

The decarboxylative alkynylation of (hetero)­aryl carboxylic acids with terminal alkynes has been achieved by using a Pd­(PPh3)4/PCy3 catalyst. This Pd-catalyzed method exhibits good functional group tolerance for both coupling partners and enables chemical modification of complex molecules. The establishment of this decarboxylative alkynylation reaction is attributed to the discovery of a highly selective decarboxylative bromination of (hetero)­aryl carboxylic acids with NBS (N-bromo­succinimide).