Reactive oxygen species activate differentiation gene transcription of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway.

Chung Fan Lam, Hoi Ting Yeung,Yuk Man Lam,Ray Kit Ng

Leukemia Research（2018）

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摘要

•Early ROS elevation triggers cell cycle arrest in leukemia cells.•Maintenance of cellular ROS is crucial to the terminal differentiation process.•Prolonged ROS elevation activates JNK/c-JUN signaling pathway.•JNK/c-JUN signaling activates leukemia cell differentiation gene expression.

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关键词

Reactive oxygen species,Acute myeloid leukemia,JNK/c-JUN signaling pathway,Terminal differentiation

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