Unveiling the Mutational Mechanism of the Bacterial Genotoxin Colibactin in Colorectal Cancer.

Bhupesh K Thakur,Yann Malaisé,Alberto Martin

Molecular cell（2019）

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摘要

In a recent issue of Science, Wilson et al. (2019) provide direct evidence that the bacterial-produced colibactin alkylates DNA in vivo, resulting in DNA adducts, which mediates its genotoxic effect. This work reinforces the role of colibactin-producing bacteria in colon cancer pathogenesis.

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