A comparative cost analysis of the Vaccination Program for US-bound Refugees.

•Vaccination Program for US-bound Refugees (VPR) provides selected vaccines overseas.•VPR reduces vaccination costs for refugees across all age groups.•Net savings per person vary from $226 (Medicaid rates for domestic costs) to $498 (private sector).•Annual cost savings with VPR are $15.8–34.9 million (Medicaid-private sector) for 70K refugees.•VPR reduces risks of refugees with potential for vaccine-preventable diseases outbreaks in the US.