Screening of over 1000 Indian Patients with Breast And/or Ovarian Cancer with a Multi-Gene Panel: Prevalence of BRCA1/2 and Non-Brca Mutations

Jaya Singh,Nishita Thota，Ramesh Hariharan,Ashraf U. Mannan

Breast Cancer Research and Treatment（2018）

Cited 63|Views10

Abstract

Breast and/or ovarian cancers are among the most common cancers in women across the world. In the Indian population, the healthcare burden of breast and/or ovarian cancers has been steadily rising, thus stressing the need for early detection, surveillance, and disease management measures. However, the burden attributable to inherited mutations is not well characterized.

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Key words

Breast cancer,Next-generation sequencing,Multi-gene panel,BRCA1,BRCA2

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Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance

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