Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.

Julie Wieseler,Amanda Ellis,Andrew McFadden, Kendra Stone,Kimberley Brown, Sara Cady,Leandro F Bastos,David Sprunger,Niloofar Rezvani,Kirk Johnson,Kenner C Rice,Steven F Maier,Linda R Watkins

Brain Research（2017）

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摘要

•Migraine facial allodynia was modeled in male rats by supradural “inflammatory soup”.•Proinflammatory mRNAs increased in trigeminal n. caudalis as a result.•Facial allodynia was prevented by 3 chemically diverse glial modulatory drugs.

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关键词

AUC,DAMPs,DRG,HMGB1,IL-1,MIF,Sp5C,TLR4,TNF

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