Potential impurities in drug substances: Compound-specific toxicology limits for 20 synthetic reagents and by-products, and a class-specific toxicology limit for alkyl bromides

J.P. Bercu,S.M. Galloway, P. Parris,A. Teasdale, M. Masuda-Herrera,K. Dobo,P. Heard,M. Kenyon,J. Nicolette,E. Vock, W. Ku,J. Harvey, A. White,S. Glowienke,E.A. Martin,L. Custer, R.A. Jolly,V. Thybaud

Regulatory Toxicology and Pharmacology（2018）

Cited 34|Views64

No score

Key words

Drug substance,Impurities,Threshold of toxicological concern (TTC),Acceptable intake (AI),Permissible daily exposure (PDE),Compound-specific limit,Class-specific limit,Monofunctional alkyl bromides

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined