Prevention of chronic renal allograft rejection by AS2553627, a novel JAK inhibitor, in a rat transplantation model.

Koji Nakamura,Yuka Kawato,Yoko Kaneko,Kaori Hanaoka,Kaori Kubo,Tomonori Nakanishi,Masashi Maeda,Hidehiko Fukahori,Misato Ito,Takahisa Noto,Masamichi Inami,Jun Hirose,Tatsuaki Morokata

Transplant Immunology（2018）

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摘要

•The effect of AS2553627, a JAK inhibitor, on chronic rejection was investigated in rat renal transplantation model.•AS2553627 improved kidney dysfunction and inhibited interstitial fibrosis/tubular atrophy and glomerulosclerosis.•AS2553627 also reduced intragraft fibrosis/epithelial–mesenchymal transition and inflammation-related gene expression.

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关键词

CsA,DSA,ECM,EMT,GFR,IF/TA,JAK,KIM-1,MHC,TAC,TIMP-1,TYK2

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